W. A. Nagle, Ph.D.

Representative Publications

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Recent Work:

Fan, K and Nagle WA, Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome. BMC Pulmonary Medicine 2002, 2:5
                     
                               http://www.biomedcentral.com/1471-2466/2/5  )

Henle KJ, Jethmalani SM, Nagle WA, Stress proteins and glycoproteins (Review), Int. J. Mol. Med. 1: 25-32, 1998

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Heat-Induced Stress Proteins

Henle, KJ, Jethmalani, SM, Nagle, WA, Heat stress-induced protein glycosylation in mammalian cells, Trends in Glycoscience and Glycotechnology 7(#35): 191-204, 1995.

Henle KJ, Kaushal GP, Nagle WA, Nolen GT, Prompt protein glycosylation during acute heat stress, Exptl. Cell Res. 207: 245-251, 1993

Henle KJ, Nagle WA, Inhibition of heat shock protein synthesis and protein glycosylation by stepdown heating. Exp. Cell Res. 196: 184-191, 1991.

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Cold-Induced Apoptosis

Nagle WA, Soloff BL, Moss AJ JR, Henle KJ, Cultured Chinese hamster cells undergo apoptosis after exposure to cold but non-freezing temperatures.  Cryobiology, 27:439-451, 1990

Soloff BL, Nagle WA, Moss AJ, Henle KJ, Crawford JT, Apoptosis induced by cold shock in vitro is dependent on cell growth phase.  Biochem Biophys Res Commun  145: 876-883, 1987

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Heat-Induced Cell Killing

Henle KJ, Cunningham MA, Nagle WA, Moss AJ, Protection against heat-induced cell killing by alanine.  Int J Hyperthermia  4: 323-331, 1988

Nagle WA, Moss AJ JR, Henle KJ, Sensitization of cultured Chinese hamster cells to 42°C hyperthermia by inhibition of glycolytic ATP synthesis with pentalenolactone.  Int J Radiat Biol  48: 821-835, 1985

Henle KJ, Monson TP, Nagle WA, Moss AJ Jr, Heat protection by sugars and sugar analogs. Int J Hyperthermia  1: 371-382, 1985

Nagle WA, Moss AJ Jr, Inhibitors of poly(ADP-ribose) synthetase enhance the cytotoxic­ity of 42°C and 45°C hyperthermia in cultured Chinese hamster cells.  Int J Radiat Biol 44: 475-481, 1983

Nagle WA, Moss AJ JR, Baker ML, Increased lethality from 42°C hyperthermia for hypoxic Chinese hamster cells heated under conditions of energy deprivation.  Natl. Cancer Inst Monograph 61: 107-110, 1982

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DNA Damage & Repair

Nagle WA, Moss AJ JR, Roberts HG JR, Baker ML, Effects of 5-thio-D-glucose on cellular ATP levels and DNA rejoining in hypoxic and aerobic Chinese hamster cells.  Radiol­ogy 137: 203-211, 1980

Ehmann UK, Williams JR, Nagle WA, Brown JA, et al: Perturbations in cell cycle progres­sion from radio-active DNA precursors.  Nature 258: 633-636, 1975

Simpson JR, Nagle WA, Bick MD, Belli JA: Molecular nature of mammalian cell DNA in al­kaline sucrose gradients. Proc Nat Acad Sci USA 70: 3660-3664, 1973